HT2C receptor modulators

Selective 5-HT2C agonists have shown antidepressant-like effects in several animal models of depression [5]. Of the recently identified 5-HT2C agonists, Ro 60-0175, WAY-161503, and WAY-163909 have been the most extensively characterized in depression models. Results in chronic mild stress and olfactory bulbectomy models of depression suggest a more rapid onset of antidepressant action: typical antidepressants require 2-3 weeks of dosing to show effectiveness, while 5-HT2C agonists are active in less than one week in both models.

5-HT2C antagonists may also have a role in the treatment of depression. It has been shown that the 5-HT2C antagonists SB-242084 and RS 102221 potentiate the action of the SSRI citalopram on rat cortical and hippocampal 5-HT levels, although the 5-HT2C antagonists alone had no effect [31]. It has also been claimed that the clinical antidepressant efficacy of agomelatine, a melatonin agonist, may be in part due to 5-HT2C antagonism [32].

Was this article helpful?

0 0
Sleeping Sound

Sleeping Sound

Get All The Support And Guidance You Need To Be A Success At Sleeping Well. This Book Is One Of The Most Valuable Resources In The World When It Comes To Getting The Rest You Need For Good Health.

Get My Free Ebook

Post a comment