Inhibitors

Craig D. Boyle, Timothy J. Kowalski and Lili Zhang

Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA

Contents

1. Introduction 127

2. 11 b-HSD Isozymes 128

3. Potential therapeutic indications 130

4. 11P-HSD1 Inhibitors 131

4.1. Thiazole-based inhibitors 131

4.2. Triazole-based inhibitors 133

4.3. Amide-based inhibitors 133

4.4. Miscellaneous inhibitors 134

5. Conclusion 135 References 135

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