PGD2 Antagonists

Julio C. Medina and Jiwen Liu

Amgen Inc., South San Francisco, CA 94080, USA

Contents

1. Introduction 221

2. DP Antagonists 223

2.1. Early DP antagonists and their related analogs 223

2.2. 3-Indole acetic acid derivatives 223

2.3. 4-Indole acetic acid derivatives 224

2.4. Other indole derivatives 225

2.5. Benzimidazole derivatives 225

2.6. Phenyl acetic acid derivatives 225

3. CRTH2 Antagonists 226

3.1. 1-Indole acetic acid derivatives and related compounds 226

3.2. 3-Indole acetic acid derivatives and related compounds 228

3.3. Tetrahydroquinoline derivatives 229

3.4. Aryl acetic acid derivatives 230

3.5. Phenoxy acetic acid derivatives 230

3.6. Benzoic acid derivatives 231

4. Conclusion 231 References 232

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