Recent Developments in Antifungal Drug Discovery

Roberto Di Santo

Dipartimento di Studi Farmaceutici, Istituto Pasteur - Fondazione Cenci Bolognetti, Universita di Roma ''La Sapienza'', P.le Aldo Moro 5, 00185 Rome, Italy

Contents

Dipartimento di Studi Farmaceutici, Istituto Pasteur - Fondazione Cenci Bolognetti, Universita di Roma ''La Sapienza'', P.le Aldo Moro 5, 00185 Rome, Italy

Contents

1. Introduction

299

2. Advances in antifungals with known mechanism of action

300

2.1. Azoles

300

2.2. Polyenes

305

2.3. Allylamines

306

2.4. Echinocandins

307

2.5. Pyrimidines

309

3. Emerging antigungal agents

310

3.1. Amino acids

310

3.2. Sordarins

310

3.3. Miscellaneous

311

4. Trends in antifungal drug discovery

312

4.1. Histone deacetylase inhibitors

312

4.2. Genome approach

312

4.3. Biofilm

312

References

313

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