Recent Strategies for the Development of New Antidepressant Drugs

Deborah A. Evrard

Chemical & Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ, USA Contents

1. Introduction

23

2. Monoamine reuptake inhibitors

24

2.1. SNRIs

24

2.2. Triple reuptake inhibitors

25

3. SSRIs with monoaminergic receptor modulation

26

3.1. SSRI + 5-HT1A antagonism

26

3.2. SSRI + 5-HT1D antagonism

28

3.3. SSRI +a2 antagonism

28

4. Serotonergic receptor modulation

29

4.1. 5-HT1A/1B/1D antagonists

29

4.2. 5-HT2C receptor modulators

30

4.3. 5-HT7 receptor antagonists

30

5. Neuropeptide receptor modulation

31

5.1. Neurokinins

31

5.2. Corticotropin-releasing factor

31

5.3. Melanocortin MC4 antagonists

33

5.4. MCH1 antagonists

33

5.5. Galanin

35

5.6. Vasopressin

35

6. Conclusion

36

References

36

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