Therapeutics

Xiangping Qian, Andrew A. Wolff and Gustave Bergnes

Cytokinetics, Inc., 280 E Grand Ave, South San Francisco, CA 94080, USA

Contents

1. Introduction 263

2. Inhibitors of kinesin spindle protein 263

2.1. Ispinesib and related compounds 264

2.2. Monastrol analogs 267

2.3. Tetrahydro-b-carbolines 268

2.4. Dihydropyrroles and dihydropyrazoles 269

2.5. Tetrahydroisoquinolines 270

3. Conclusions 271 References 272

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