What is autoimmunity

Autoimmunity is an immune reaction against "self." Autoimmune disease implies that tissue damage is a result of an autoimmune (autoallergic) reaction. This may be the result of antibody production or as a result of lymphocytes (CD4+) causing damage directly or in concert with macrophages. There is a third type of immunologic reaction, an antibody-mediated tissue damage in which different lymphocytes (CD8+) cause additional damage. All three types of reactions are


The consequence of the arousal of the immune system leading to antibody production or a cellular (lymphocyte) reaction directed against tissues in ones own body (antigens).

thought to play a role in some patients with MS. Recent evidence implicates CD8+ cells in attacks of demyelinating disease called acute disseminated encephalomyelitis that, although resembling MS, does not relapse. It is like a "single attack of MS" type of disease.

Pathology the scientific study of disease. It is also a term used to describe detectable damage to tissues.

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