Nail melanoma

Melanoma of the nail apparatus most commonly derives from the matrix, much less frequently from the nail bed or hyponychium. Matrix melanoma usually causes longitudinal melanonychia (see Chapter 5). Whether atypical melanocytic hyperplasia is already subungual in situ melanoma is not entirely clear. Large, atypical melanocytes in all layers of the matrix and nail bed epithelium, pycnotic melanocytes in the nail plate mirroring the pagetoid spread in the epithelium, and mitoses, are seen as proof of a malignant melanoma. Sometimes nail clippings reveal single intraungual pycnotic melanoma cells which retain their protein S-100 positivity.

Most subungual melanomas are of acrolentiginous type; however, those in the nail bed tend instead to be nodular melanomas. Even long-standing melanomas are often still very superficial. Invasive melanomas have therefore usually a decade-long history.

How To Prevent Skin Cancer

How To Prevent Skin Cancer

Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.

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