The autoimmune bullous disorders do not exhibit specific features differentiating them from skin lesions. Pemphigus vulgaris may involve the matrix and nail bed with suprabasal acantholytic cleft formation and subsequent nail thinning. Bullous pemphigoid is characterized by a subepithelial cleft formation and an eosinophil-rich infiltrate. Cicatricial pemphigoid rarely involves the nail and may cause considerable nail dystrophy. Immunofluorescence examinations, sometimes enzyme-linked immunosorbent assay (ELISA), immunoblotting and immunoprecipitation, are necessary to distinguish these dermatoses.
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.