And neurogenesis
Nodose neurons are derived from the nodose placode, the most caudal of the epi-branchial series of placodes that forms above the pharyngeal (branchial) clefts (Figure 1.2, see Section 1.2.4). In this section, the formation of placodes in general, and the epibranchial placodes in particular, are described, followed by a discussion of our current understanding of the control of neurogenesis within the epibranchial placodes (geniculate, petrosal and nodose). As will be seen, nothing is currently...
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Trunk during the early stages of diabetes results in an increased availability of the vagal afferent and or efferent neuronal perikarya to NGF. 2.4.2.1.2 Neurotrophin Content in Peripheral Targets of the Vagus Nerve The effects of diabetes on the contents of NGF and NT-3 protein and mRNAs are studied in tissues innervated by the vagus nerve (Reference 132 and Cai, Lee, and Helke, unpublished data). Using RT-PCR, NGF and NT-3 mRNAs are detected in multiple targets tissues of the vagus nerve,...
Development and sensory neurogenesis
Jugular neurons arise from neural crest cells that emigrate from the postotic hind-brain, at the level of the first three somites8,12 (see Figure 1.2A and Figure 1.3). In this section, a brief description is given of our current understanding of neural crest induction at the neural plate border, followed by a general discussion of lineage diversification within the neural crest. Finally, recent progress in elucidating the mechanisms underlying neural crest cell adoption of a sensory neuronal...
Frontiers In Neuroscience
Hannun, M.D., Professor of Biomedical Research and Chairman Department of Biochemistry and Molecular Biology, Medical University of South Carolina Rose-Mary Boustany, M.D., tenured Associate Professor of Pediatrics and Neurobiology, Duke University Medical Center Methods for Neural Ensemble Recordings Miguel A.L. Nicolelis, M.D., Ph.D., Professor of Neurobiology and Biomedical Engineering, Duke University Medical Center Methods of Behavioral Analysis in Neuroscience Jerry J....
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Neural crest-derived neurons B Placode-derived neurons FIGURE 1.2 A Schematic to show the location of cranial ectodermal placodes in a 3-day chick embryo. Each of the four epibranchial placodes geniculate, petrosal, and two nodose placodes is located just caudal to a pharyngeal cleft. The bi-lobed trigeminal ganglion is already forming. gen, geniculate placode nod, nodose placode pet, petrosal placode ves, vesicle. Adapted from Le Douarin, N.M., Fontaine-Perus, J., and Couly, G., Trends...
Contributors
Biomedical Engineering Program Purdue School of Engineering and Technology Indiana University Purdue University Indianapolis, Indiana Department of Anatomy University of Cambridge United Kingdom Department of Biomedical Science University of Sheffield Sheffield, United Kingdom and Gastrointestinal Diseases Research Unit Queen's University Kingston, Ontario, Canada Department of Pharmacology School of Medicine University of California, Davis Davis, California Centre for Neuroscience Flinders...
Effect Of Vagus Nerve Damage And Disease On Neurotrophins Associated With Vagal Afferent Neurons
2.4.1 Neurotrophin and Neurotrophin Receptor mRNAs after Vagus Nerve Injury Neurotrophins and neurotrophin receptors play an important role in survival and growth of injured peripheral nerves. The injury-mediated neurotrophic response in autonomic nerves has been investigated by studying changes in mRNA expression of neurotrophins and their receptors in the transected vagus nerve and nodose ganglion.76,134 The presence and distribution of neurotrophin and neurotrophin receptor mRNAs in the...
Epigenetic Influences On Maintenance Of Mature Vagal Afferent Neurons
2.3.1 Epigenetic Influences on Neurochemistry of Mature Vagal Afferent Neurons Multiple neurotransmitters, neuropeptides, calcium binding proteins, and other neu-roactive substances are associated with vagal afferent neurons of the nodose gan-glion.253 The neurochemistry of the nodose ganglion was initially studied with the histochemistry and immunoassay, and subsequently with immunohistochemistry, in situ hybridization histochemistry, and RT-PCR. Putative neurotransmitters glutamate,...
