Figure 4.15. A common finding in trisomy 13 is bilateral cleft lip and palate. In this infant there is microcephaly, hypotelorism, the eyes are microphthalmic, and there is a receding forehead. On further study the infant had an alobar holoprosencephaly. In trisomy 13, central nervous system abnormalities are found in 50% or more of infants and, hence, one should check for a holo-prosencephaly defect.
Figure 4.16. The same infant also had an omphalocele. The finding of cleft lip and palate with an omphalocele or large umbilical hernia should alert one to the possibility of the diagnosis of trisomy 13.
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