Can Cornelia De Lange Syndrome Be Prevented

Hypertrichosis Newborn

Figure 1.97. Hypertrichosis in a Hispanic infant whose mother was an epileptic treated with pheny-toin throughout her pregnancy. Hypertrichosis is associated with syndromes such as Cornelia de Lange's, leprechaunism, etc. In infants with hypertrichosis associated with syndromes, there may be a low anterior hairline which is especially noted at the sides of the forehead approaching the lateral eyebrows due to a widened "side-burn."

Figure 1.97. Hypertrichosis in a Hispanic infant whose mother was an epileptic treated with pheny-toin throughout her pregnancy. Hypertrichosis is associated with syndromes such as Cornelia de Lange's, leprechaunism, etc. In infants with hypertrichosis associated with syndromes, there may be a low anterior hairline which is especially noted at the sides of the forehead approaching the lateral eyebrows due to a widened "side-burn."

Figure 1.98. Hypertrichosis in an infant with Cornelia de Lange's syndrome. Note also the synophrys, anteverted nostrils, and lack of philtrum. Synophrys (bridging of the eyebrows in the midline) is seen in Cornelia de Lange's syndrome, Waardenburg's syndrome, and in otherwise normal infants. The skin between the eyebrows usually bears only fine vellus hairs, and when the brows encroach on this area they produce the appearance of a single band of hair above the eyes. Straight eyelashes emerge from the lid margin at a steep angle and extend straight downward rather than exhibiting the gentle upward curve. Such eyelashes are seen in children with severe neuromuscular disease and may be caused by lack of normal muscle tone in the leva-tor palpebri superioris muscle.

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  • Azzeza
    Can cornelia de lange syndrome be prevented?
    3 years ago

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