Effect of Hyperinsulinemia on Anovulation in PCOS

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Numerous studies have demonstrated that hyperinsulinemia contributes to the chronic anovulation of PCOS. In the largest long-term study, 305 women with PCOS were randomized to the insulin sensitizer troglitazone (150, 300, or 600 mg daily) or placebo for 44 weeks (10). Women receiving troglitazone at doses of 300 and 600 mg daily had a significantly higher ovulation rate (0.42 and 0.58) than those receiving placebo (0.32; p < 0.05 and 0.0001, respectively). This increase in ovulation rate was dose dependent, suggesting that the improvement in ovulatory function was at least in part accounted for by the improvement in insulin sensitivity.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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