Effect of Hyperinsulinemia on Hyperandrogenism in PCOS

The Natural Pcos Diet

Holistic Solution to get rid of Polycystic Ovary Syndrome

Get Instant Access

Several lines of evidence suggest that the compensatory hyperinsulinemia associated with insulin resistance is critical to the pathogenesis of hyperandrogenism in PCOS. In in vitro cultures of isolated human ovarian thecal cells, ovarian testosterone biosynthesis stimulated by insulin was fourfold greater in cells from women with PCOS than those of normal women, and in a dose-response study insulin stimulated thecal androgen production at physiological concentrations (3). This stimulation of testosterone production was almost fully prevented by antibody blockade of the insulin receptors. This suggests that insulin stimulates ovarian thecal testosterone biosynthesis via activation of its homologous receptor.

Insulin also decreases circulating levels of sex hormone-binding globulin (SHBG), the primary circulating binding protein for testosterone (4). Because of testosterone's high-affinity binding to SHBG, lower SHBG levels translate to increased levels of free and bioavailable testosterone to target tissues. In addition, insulin may also influence secretory dynamics of gonadotropins by the pituitary, resulting in further stimulation of ovarian androgen production (5-7).

In vivo data also suggest that hyperinsulinemia is associated with an increased level of circulating testosterone in PCOS. When pancreatic insulin secretion was suppressed in women with PCOS by diazoxide, both serum total and free testosterone levels decreased (8). However, diazoxide's suppression of insulin release in healthy normal women did not result in changes in serum testosterone levels (9). Hence, hyperinsulinemia seems to play a role in hyperandrogenemia in PCOS, and women with PCOS may be more susceptible than normal women to stimulation of ovarian androgen production by insulin.

Was this article helpful?

0 0
Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook


Post a comment