Long Term Health Consequences of PCOS

Insulin resistance is associated with diabetes, hypertension, dyslipidemia, endothelial dysfunction, a procoagulant state, and cardiovascular disease (see Chapters 28 and 29). Recently, the National Cholesterol Education Program Adult Treatment Panel defined the metabolic syndrome as the presence of three of the five following risk factors: waist circumference greater than 88 cm in females; fasting serum glucose 110 mg/dL or more, fasting serum triglycerides greater than 150 mg/dL; serum high-density lipoprotein cholesterol less than 50 mg/dL; and blood pressure greater than 130/85 mmHg (60). The metabolic syndrome has been found to be present in 43-46% of women with PCOS, a twofold higher prevalence compared with women in the general population of the same age (61,62).

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