Preface

Over recent decades new insights have been obtained surrounding the concepts of the regulation of the onset of puberty. However, human puberty remains a mystery. The mechanisms responsible for suppression and reawakening of the GnRH pulse generator from fetal life into puberty still need to be elucidated. However, many genetic and environmental factors have been identified modulating the pubertal process. This book on the abnormalities of puberty gives an overview on the latest knowledge in the...

Fetal Nutrition and Timing of Puberty

Engelbregt, M.A. Veening, H.A. Delemarre-van de Waal Department of Pediatrics, Research Institute for Clinical and Experimental Neurosciences, VU University Medical Center, Amsterdam, The Netherlands Over the last decade growing evidence has been documented on the relationship between intrauterine growth retardation (IUGR) and pubertal development indicating changes in timing and progression of puberty. These changes in pubertal development are part of a growing...

Secular Trend of Timing of Puberty

Central Precocious Puberty Pictures

VU University Medical Center, Amsterdam, The Netherlands During the last decades, a secular trend of growth and timing of puberty occurred consisting of increased adult height and earlier onset of puberty. In The Netherlands although the most recent survey showed an increase of final height again, the timing of puberty onset appears to level off, and in boys pubertal onset was even slightly retarded. Different findings were reported from the United States, where a strong advancement of the...

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Progression of puberty from B2 to B3 or B4 in girls with idiopathic central precocious puberty. The broken line indicates approximate mean progression, calculated from transversal data in healthy Dutch girls 51 . Fig. 3. Progression of puberty from B2 to B3 or B4 in girls with idiopathic central precocious puberty. The broken line indicates approximate mean progression, calculated from transversal data in healthy Dutch girls 51 . gonadal steroids and gonadotropin secretion. Treatment...