Agents Used In Renal Transplantation

Drug

Dosage

Adverse reactions

Cost

Cyclosporine

Starting dose: 7-10 mg/kg/d in

Nephrotoxicity, hypertension, gingival over-

Gelcaps: $1.61/25 mg;

Sandimmune

2 divided doses

growth, hirsutism, hepatotoxicity, neurotoxicity,

$6.42/100 mg

(Sandoz Pharmaceuticals, East Hanover, NJ)

Maintenance: based on blood levels

hypomagnesia, hyperkalemia

Liquid: $6.41/100 mg, orally

Neoral

Starting dose: 7-10 mg/kg/d in

Same

Gelcaps: $1.44/25 mg;

(Sandoz Pharmaceuticals, East Hanover, NJ)

2 divided doses

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