Distinctive Features Of Membranoproliferative Glomerulonephritis Or Cryoglobulinemic Glomerulonephritis

Exudative component

The major constituent of intracapillary proliferation is an infiltration of leukocytes, mainly monocytes, that sometimes is massive.

Intraluminal thrombi

Huge deposits of cryoglobulins called intraluminal thrombi sometimes fill the capillary lumen.

Interposition of monocytes in the double contour of the capillary wall

Monocytes, in close contact with the subendothelial deposits of cryoglobulins, are interposed between the glomerular basement membrane and the newly formed membranelike material, to give the double-contoured appearance of the capillary wall, whereas peripheral interposition of mesangial matrix and cells is moderate.

Structured crystalloid deposits on electron microscopy

Intraluminal and subendothelial deposits of cryoglobulins sometimes show a specific fibrillar structure on electron microscopy.

Vasculitis of small and medium-sized arteries

Necrotizing arteritis, without concomitant features of segmental necrotizing glomerulonephritis, is found in one third of patients.

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