Figure 1013

Calcium oxalate crystals seen by electron microscopy in transplant acute tubular necrosis.

FEATURES OF TRANSPLANT ACUTE TUBULAR NECROSIS (ATN) WHICH DIFFERENTIATE IT FROM NATIVE KIDNEY ATN

1. Apparently intact proximal tubular brush border

2. Occasional foci of necrosis of entire tubular cross sections

3. More extensive calcium oxalate deposition

4. Significantly fewer tubular casts

5. Significantly more interstitial inflammation

6. Less cell-to-cell variation in size and shape ("tubular cell unrest")

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