Figure 1018

Antiviral activation and action (acyclovir, valacyclovir, famciclovir, ganciclovir). Resistance (R) to antivirals has been found at the level of viral thymidine kinase (R1) and DNA polymerase (R2). Ganciclovir is monophosphory-lated in cytomegalovirus (CMV)-infected cells by the CMV UL97 gene product. Acyclovir, valacyclovir, and famciclovir are not easily phosphorylated in CMV-infected cells. Cidofovir does not require viral enzymes to be phosphorylated to the active diphosphonate.

DRUG INTERACTIONS BETWEEN ANTIVIRALS, ANTIFUNGALS, ANTIBACTERIALS, ANTIMYCOBACTERIALS, AND ANTIPROTOZOALS WITH CYCLOSPORINE AND FK506

Drug

Effect on CSA/FK506

Nephrotoxicity of combination

Antifungals

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