Figure 1025

Pathogenesis of cyclosporine nephropathy. Chronic administration of cyclosporine may induce sustained renal vasoconstriction. Impairment of renal blood flow leads to tubuloin-terstitial fibrosis. Cyclosporine increases the recruitment of renin-containing cells along the afferent arteriole. Hyperplasia of the juxtaglomerular apparatus increases angiotensin II levels that, in turn, stimulate tumor growth factor-^ (TGF-|3) secretion, resulting in interstitial fibrosis [20].

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