Figure 1026

Cyclosporine (CyA) nephrotoxicity in nonrenal diseases. A, Patients treated with cyclosporine (7.5 mg/kg) for psoriasis experienced a median decrease to 84% of the initial values in the glomerular filtration rate after 8 weeks of therapy. B, Of patients treated with cyclosporine (9.3 mg/kg) for autoimmune diseases, 21% showed cyclosporine nephropathy on biopsy, with a decrease to 60% of the initial values in renal function. C, Patients with cardiac transplantation treated with high doses of cyclosporine (10 to 6 mg/kg) developed a reduction to 57% of the initial values in renal function 36 months after transplantation. Patients treated with azathioprine did not show any reduction in renal function. D, Patients receiving cyclosporine (5 mg/kg) for uveitis for 2 years showed a decrease in glomerular filtration rate to 65% of the initial values. (Panel A adapted from Ellis and coworkers [23]; panel B adapted from Feutren and Mihatsch [24]; panel C adapted from Myers and Newton [25]; and panel D adapted from Deray and coworkers [26].)

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