Figure 1027

A positive family history is a risk factor for preeclampsia, and the incidence is approximately 4 times greater in first-degree relatives of index cases [23]. Cooper and coworkers [24] also noted an increased incidence in relatives by marriage (eg, daughter-in-laws), and 10 instances in which the disease occurred in one but not the other monozygotic twin. These data raise the possibility of paternal or fetal genetic influence [24]. The mode of inheritance of preeclampsia is not known. Several possibilities have been suggested, includ ing a recessive gene with the possibility of a maternal-fetal genotype-by-genotype interaction or a dominant maternal gene with incomplete penetrance.

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