Figure 1027

Morphology of cyclosporine nephropathy on renal biopsy of a patient with cardiac transplantation. Two different types of lesions are seen in cyclosporine nephropathy. A, Arteriolopathy: Hyalin, paucicellular thickening of the intima with focal wall necrosis results in narrowing of the vascular lumen (magnification X 300

periodic acid-Schiff reaction). B, A striped form of interstitial fibrosis characterized by irregularly distributed areas of stripes of interstitial fibrosis and tubular atrophy in the renal cortex. Tubules in other areas were normal (magnification x 100 periodic acid-Schiff reaction).

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