Figure 1034

Functional renal alterations in preeclampsia. The functional consequences of glomerular endotheliosis and of the hormonal alterations in preeclampsia are summarized in this schematic diagram of the nephron in preeclampsia. Suppression of the renin-angiotensin system occurs, probably in response to vasoconstriction and elevated blood pressure. The glomerular lesion leads to proteinuria, which may be heavy. Renal hemodynamic changes include modest decreases in the glomerular filtration rate (GFR) and renal blood flow (RBF). Decreased sodium and uric acid excretion may be caused by increased proximal tubular reabsorption. The mechanism for the marked hypocalciuria is not known.

Trial

Number of trials

Antiplatelet therapy

Control therapy

Odds ratio and 95% Cl (horizontal line) (antiplatelet: placebo)

Smaller studies (<200 women)

0 0

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