Figure 1036

Prevention of preeclampsia using calcium supplementation. Another preventive strategy that has been extensively investigated, with conflicting outcomes, is calcium supplementation. The rationale for this approach is based on the observations that low dietary calcium intake may increase the risk for preeclampsia, and that preeclampsia is characterized by abnormalities in calcium metabolism that suggest a calcium deficit, eg, decreased vitamin D and hypocalciuria [31]. A recent meta-analysis of 14 trials of calcium supplementation in pregnancy concluded that calcium supplementation during pregnancy leads to reductions in blood pressure and a lower incidence of preeclampsia. In contrast, a large randomized trial of calcium supplementation in 4589 low-risk women failed to demonstrate a benefit of calcium therapy [31]. CI—confidence interval; OR—odds ratio. (From Bucher and coworkers [30]; with permission.)

Close monitoring of maternal and fetal conditions Hospitalization in most cases Lower blood pressure for maternal safety Seizure prophylaxis with magnesium sulfate Timely delivery

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