Figure 1047

Renal and hepatic outcome in patients treated with interferon alpha post-renal transplant for hepatitis C virus (HCV) infection. Interferon treatment results in a high rate of transplant acute renal failure or rejection. Transplant biopsies in those with acute renal failure show severe diffuse edema. Acute renal failure is not very responsive to steroids. Virologic clearing is rare, as HCV-RNA is detectable, on average, 1 month after discontinuing interferon if the polymerase chain reaction (PCR) became negative during treatment. ALT— alanine aminotransferase; SC—subcuta-neously; TIW—three times a week. (Data from Thervet and coworkers [21], Magnone and coworkers [22], Rostaing and coworkers [23,24], and Yasumura and coworkers [25].)

*Most are overlapping patients with the 1995 study.

0 0

Post a comment