Figure 107

Transmural arteritis with fibrinoid change. In addition to the influx of inflammatory cells there has been proliferation of modified smooth muscle cells migrated from the media to the greatly thickened intima. Note the fibrinoid change at lower left and the penetration of the media by inflammatory cells at the upper right. Patients with these types of lesions have a less favorable prognosis, greater graft loss, and poorer long-term function as compared with patients with intimal arteritis alone. These sorts of lesions are also common in antibody-mediated rejection (see Fig. 10-9).

0 0

Post a comment