Figure 1117

Mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) disrupt the compensatory vasodilatation response of renal prostaglandins to vasoconstrictor hormones in patients with prerenal conditions. Most of the renal abnormalities encountered clinically as a result of NSAIDs can be attributed to the action of these compounds on prostaglandin production in the kidney [31].

Sodium chloride and water retention are the most common side effects of NSAIDs. This should not be considered drug toxicity because it represents a modification of a physiologic control mechanism without the production of a true functional disorder in the kidney.

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