Figure 115

Evolution of monoclonal antilymphocytic antibodies. Monoclonal antibodies are the result of complex genetic engineering techniques. A, Differences among murine, chimeric, and "humanized" antibodies. Attempts to reduce side effects, improve efficacy, and decrease xenosensitization are the main reasons for development of these modifications on the murine molecule. B, The different monoclonal antibodies, their classification regarding the molecular structure, and their targets. Muromonab OKT3 (Ortho Pharmaceutical, Raritan, NJ) is the only monoclonal antibody commercially available at this time [6]. CD3— monomorphic membrane co-receptor present in T-lymphocytes; IL-2R—interleukin-2R; TCR—T-cell receptor.

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