Figure 116

Experimental model of the vasoconstrictive effect of cyclosporine. Some of the acute nephrotoxicity of cyclosporine is due to the significant yet reversible vasoconstrictive effect of the drug. A, Scanning electron micrograph of glomerulus of a rat not exposed to cyclosporine. Arrow indicates glomerular capillary loop. AA—afferent artery. B, After 14 days of cyclosporine treatment, the entire length of an afferent arteriole shows narrowing (magnification X 500). Arrow indicates afferent artery. (From English and coworkers [7]; with permission.)

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