Figure 118

RISK FACTORS FOR AMINOGLYCOSIDE NEPHROTOXICITY I Risk factors for aminoglycoside nephro-

toxicity. Several risk factors have been identified and classified as patient related, aminoglycoside related, or related to concurrent administration of certain drugs.

The usual recommended aminoglycoside dose may be excessive for older patients because of decreased renal function and decreased regenerative capacity of a damaged kidney. Preexisting renal disease clearly can expose patients to inadvertent overdosing if careful dose adjustment is not performed. Hypomagnesemia, hypokalemia, and calcium deficiency may be predisposing risk factors for consequences of aminoglycoside-induced damage [13]. Liver disease is an important clinical risk factor for aminoglycoside nephrotoxicity, particularly in patients with cholestasis [13]. Acute or chronic endotoxemia amplifies the nephrotoxic potential of the aminoglycosides [14].

0 0

Post a comment