Figure 119

Prevention of aminoglycoside nephrotoxicity. Coadministration of other potentially nephrotoxic drugs enhances or accelerates the nephrotoxicity of aminoglycosides. Comprehension of the phar-macokinetics and renal cell biologic effects of aminoglycosides, allows identification of aminoglycoside-related nephrotoxicity risk factors and makes possible secondary prevention of this important clinical nephrotoxicity.

Patient-Related Factors

Aminoglycoside-Related Factors

Other Drugs

Older age*

Recent aminoglycoside therapy

Amphotericin B

Preexisting renal disease

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