Figure 119

Proposed mechanisms of action of new immunosuppressive drugs currently undergoing clinical or preclinical trials in organ transplantation [9].

Rapamycin Inhibition of cytokine action (downstream of interleukin-2 receptor and other growth factors)

Leflunomide Inhibition of cytokine action (expression of or signaling by way of interleukin-2 receptor)

Inhibition of DNA and RNA synthesis (pyrimidine pathway)

Brequinar Inhibition of DNA and RNA synthesis (pyrimidine pathway)

Deoxyspergualin Unknown (related to heat-shock proteins?)

SKF-105685 Unknown (stimulation of suppressor cells?)

Mizoribine Inhibition of DNA and RNA synthesis (de novo purine pathway)

CTLA-4Ig Blockage of T-cell co-stimulatory pathway

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