Figure 11b

Mechanisms of sodium chloride reabsorption in the distal tubule. The distal convoluted tubule and subsequent connecting tubule have a variety of sodium transport mechanisms. The distal tubule has predominantly a sodium chloride cotransporter, which is inhibited by thiazide diuretics. In the connecting tubule, sodium channels and a sodium-hydrogen exchange mechanism also are present. Amiloride inhibits sodium channel activity. Again the sodium-potassium ATPase (Na+-K+ ATPase) on the basolateral membrane provides most of the driving force for sodium reabsorption.

Collecting duct principal cell

Lumen

Amiloride

Cell

Collecting duct principal cell

Cell

Lumen

Amiloride

Regulation of reabsorbtion Stimulation Aldosterone 3Na+ Antidiuretic hormone

2 K+ Inhibition

Prostaglandins Nitric oxide

Atrial natriuretic peptide Bradykinin

Regulation of reabsorbtion Stimulation Aldosterone 3Na+ Antidiuretic hormone

2 K+ Inhibition

Prostaglandins Nitric oxide

Atrial natriuretic peptide Bradykinin

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