Figure 121

Inherited renal tubular disorders generally are transmitted as autosomal dominant, autosomal recessive, X-linked dominant, or X-linked recessive traits. For many of these disorders, the identification of the disease-susceptibility gene and its associated defective protein product has begun to provide insight into the molecular pathogenesis of the disorder.

AD—autosomal dominant; AR—autosomal recessive; ClC-K2—renal chloride channel; NCCT—thlazlde-sensltlve cotransporter; NKCC2—bumetanide-sensitive cotransporter; ROMK—inwardly rectified.

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