Figure 1213

Familial hypokalemic, hypochloremic metabolic alkalosis, or Bartter's syndrome, is not a single disorder but rather a set of closely related disorders. These Bartter-like syndromes share many of the same physiologic derangements but differ with regard to the age of onset, presenting symptoms, magnitude of urinary potassium and prostaglandin excretion, and extent of urinary calcium excretion. At least three clinical phenotypes have been distinguished: classic Bartter's syndrome, the antenatal hypercalciuric variant (also called hyperprostaglandin E syndrome), and hypocalciuric-hypomagne-semic Gitelman's syndrome [25].

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