Figure 1221

The relationship between urine osmolality and plasma arginine vasopressin (AVP). Nephrogenic diabetes insipidus (NDI) is characterized by renal tubular unresponsiveness to the antidiuretic hormone AVP or its antidiuretic analogue 1-desamino-8-D-arginine vasopressin (DDAVP). In both the congenital and acquired forms of this disorder the clinical picture is dominated by polyuria, polydipsia, and hyposthenuria despite often elevated AVP levels [17]. (From Robertson et al. [36]; with permission.)

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