Figure 123

Angiotensin II actions on renal hemodynamics. Systemic and intrarenal angiotensin II exert powerful vasoconstrictive actions on the kidney to decrease renal blood flow and sodium excretion. At the level of the glomerulus, angiotensin II is a vasoconstrictor of both afferent (AA) and efferent arterioles (EA) and decreases the filtration coefficient Kf. Angiotensin II also directly inhibits renin release by the juxtaglomerular apparatus. Increased intrarenal angiotensin II also is responsible for the increased sensitivity of the tubuloglomerular feedback mechanism that occurs with decreased sodium chloride intake (see Fig. 1-9) [17,27,28]. BS—Bowman's space; GC—glomerular capillaries; PC—peritubular capillaries; PT—proximal tubule; TAL—thick ascending limb; TGF—tubu-loglomerular feedback mechanism. (Adapted from Arendshorst and Navar [17].)

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