Figure 124

Assessing the risks of cytomegalovirus (CMV) infection after transplantation. CMV is a major cause of morbidity and mortality after transplantation. The incidence and severity of CMV are associated with the serologic status of the donor (d) and recipient (r), the risks generally being the following: recipient negative-donor negative less than recipient positive-donor negative less than recipient negative-donor positive less than recipient positive-donor positive. As shown in these data from the United Network for Organ Sharing Scientific Registry, the rate of graft survival tends to be less in recipients of kidneys from donors who test positive for CMV infection. The serologic status of both the donor and recipient is often used to determine which patients are candidates for prophylactic or preemptive anti-CMV therapy after transplantation. (From Cecka [3]; with permission.)

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