Figure 133

Risk of acute rejection in cadaver kidney transplantation. This graph, derived from the parametric analysis techniques of Blackstone and coworkers [6], depicts the risk of acute rejection over time. Using an immunosuppressive protocol including cyclosporine, mycopheno-late mofetil, and prednisone, the risk of acute rejection is greatest during the first 2 months after transplantation, diminishing significantly afterward. Because the risk of rejection is greatest, immunosuppressive therapy is most intense during this period. Correspondingly, complications related to immunosuppressive therapy (including infections and specific drug toxicities) also are most likely during this time.

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