Figure 1413

Endothelin (ET) receptor blockade ameliorates acute cyclosporine-induced nephrotoxicity. Cyclosporine A (CSA) was administered intravenously to rats. Then, an ET receptor anatgonist was infused directly into the right renal artery. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were reduced by the CSA in the left kidney. The ET receptor antagonist protected GFR and RPF from the effects of CSA on the right side. Thus, ET contributes to the intrarenal vasoconstriction and reduction in GFR associated with acute CSA nephrotoxicity. (From Fogo et al. [6]; with permission.)

Normal basal state

Circulating levels of vasoconstrictors: Low

Afferent arteriolar tone normal

Intrarenal levels of prostacyclin: Low

Afferent arteriolar tone normal

Intraglomerular A P normal

GFR normal

Intraglomerular A P normal

GFR normal

Intravascular volume depletion

Circulating levels of vasoconstrictors: High

_ Afferent arteriolar tone normal or mildly reduced

Intrarenal levels of prostacyclin: High

Intraglomerular A P normal or mildly reduced

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