Figure 1419

Deleterious effects of nitric oxide (NO) on the viability of renal tubular epithelia. A, Hypoxia and reoxygenation lead to injury of tubular cells (filled circles); inhibition of NO production improves the viability of tubular cells subjected to hypoxia and reoxygena-tion (triangles in upper graph), whereas addition of L-arginine enhances the injury (triangles in lower graph). B, Amelioration of ischemic injury in vivo with antisense oligonucleotides to the iNOS: blood urea nitrogen (BUN), and creatinine (CR) in rats subjected to 45 minutes of renal ischemia after pretreatment with antisense phosphorothioate oligonucleotides (AS) directed to iNOS or with sense (S) and scrambled (SCR) constructs. C, Resistance of proximal tubule cells isolated from iNOS knockout mice to hypox-ia-induced injury. LDH—lactic dehydrogenase. (A, From Yu et al. [12], with permission; B, from Noiri et al. [13], with permission; C, from Ling et al. [14], with permission.)

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Iothalamate

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