Figure 1426

Effect of different scavengers of reactive oxygen metabolites and iron chelators on, A, blood urea nitrogen (BUN) and, B, creatinine in gentamicin-induced acute renal failure. The numbers shown above the error bars indicate the number of animals in each group. Benz—sodium benzoate; Cont—control group; DFO—deferoxamine; DHB— 2,3 dihydroxybenzoic acid; DMSO— dimethyl sulfoxide; DMTU—dimethylth-iourea; Gent—gentamicin group. (From Ueda et al. [23]; with permission.)

Superoxide

Iron stores

Release of Hydrogen k free iron Peroxide (HA)

Superoxide

OH*^ Hydroxyl Radical (OH-)

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