Figure 1431

Neutralizing anti-ICAM antibody ameliorates the course of ischemic renal failure with blood urea nitrogen, A, and plasma creatinine, B. Rats subjected to 30 minutes of bilateral renal ischemia or a sham-operation were divided into three groups that received either anti-ICAM antibody or its vehicle. Plasma creatinine levels are shown at 24, 48, and 72 hours. ICAM antibody ameliorates the severity of renal failure at all three time points. (Adapted from Kelly et ai. [24]; with permission.)

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