Figure 144

A, The topography of juxtaglomerular apparatus (JGA), including macula densa cells (MD), extraglomerular mesangial cells (EMC), and afferent arteriolar smooth muscle cells (SMC). Insets schematically illustrate, B, the structure of JGA; C, the flow of information within the JGA; and D, the putative messengers of tubuloglomeru-lar feedback responses. AA—afferent arteriole; PPC—peripolar cell; EA—efferent arteriole; GMC—glomerular mesangial cells. (Modified from Goligorsky et al. [1]; with permission.)

The normal tubuloglomerular (TG) feedback mechanism
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