Figure 146

Metabolic basis for the adenosine hypothesis. A, Osswald's hypothesis on the role of adenosine in tubuloglomerular feedback. B, Adenosine metabolism: production and disposal via the salvage and degradation pathways. (A, Modified from Osswald et al. [2]; with permission.)

Adenosine nucleotide metabolism

Adenosine nucleotide metabolism

^ Transporter

Phosphorylation or degradation

ATP AMP

Adenosine juj^ Inosine~jzz^>

Degradation pathway

Hypo-xanthine

^ Transporter

Phosphorylation or degradation

ATP AMP

Adenosine juj^ Inosine~jzz^>

Salvage pathway

Degradation pathway

Hypo-xanthine

Uri ic acid

Xanthine

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