Figure 1513

The general relationship between oncosis and apoptosis after nephrotoxicant exposure. For many toxicants, low concentrations cause primarily apoptosis and oncosis occurs principally at higher concentrations. When the primary mechanism of action of the nephrotoxicant is ATP depletion, oncosis may be the predominant cause of cell death with limited apoptosis occurring.

GSH-Hg-GSH -CYS-Hg-CYSs

Lumen

Proximal tubular cell

■ GSH-Hg-GSH VGLY-CYS-Hg-CYS-GLY CYS-Hg-CYS CYS-Hg-CYS Na+

Dipeptidase y-gt'

Dipeptidase

S-"-"5 Neutral amino acid transporter

GSH-Hg-GSH

Urine Acivicin

CYS-Hg-CYS

CYS-Hg-CYS GSH-Hg-GSH

Na+ a-Ketoglutarate—a-Ketoglutarate

Dicarboxylate transporter

Blood

Dicarboxylic acids a-Ketoglutarate v a-Ketoglutarate

Organic anion transporter

Organic anion transporter a-Ketoglutarate v

Organic anions à^(PAH or T probenecid) -R-Hg-R-CYS-Hg-CYS GSH-Hg-GSH

0 0

Post a comment