Figure 1528

Calpain translocation. Proposed pathways of calpain activation and translocation. Both calpain subunits may undergo calcium (Ca2+)-mediated autolysis within the cytosol and hydrolyze cytoso-lic substrates. Calpains may also undergo Ca2+-mediated translocation to the membrane, Ca2+-mediated, phospholipid-facilitated autolysis and hydrolyze membrane-associated substrates. The autolyzed calpains may be released from the membrane and hydrolyze cytosolic substrates. (From Suzuki and Ohno [10], and Suzuki et al. [11]; with permission.)

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