Figure 1610

Graft loss in young infants and children often caused by irreversible acute rejection episodes. Rejection is, perhaps, a result of heightened immune response in this age group [7]. Despite an improvement in graft survival in children over the past 5 years, the half-life of renal grafts in pediatric patients remains around 10 years [8]. This half-life means that many of these children will need a second transplantation in their lifetime. Depicted are the North American Pediatric Renal Transplant Cooperative Study data stratifying the analysis of the percentage of graft survival by donor source. A, Graft survival rates for living donor transplantations, primary and first repeat. B, Survival rates for cadaveric donor source transplantations. Graft survival rates for repeat transplantations did not correlate with early or late failure of the primary graft. (From Tejani and Sullivan [9]; with permission.)

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